The much-anticipated Lp(a)HORIZON trial testing whether the novel drug pelacarsen can improve cardiovascular outcomes by decreasing lipoprotein(a) levels has failed to meet its primary endpoint.

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Please provide your email address to receive an email when new articles are posted on . Pelacarsen did not reduce cardiovascular events in patients with elevated lipoprotein(a) compared with placebo.

The result calls into question other late-stage trials testing Lp(a)-lowering drugs from the likes of Amgen and Eli Lilly. (iStock / Getty Images Plus) Novartis’ Ionis-partnered drug designed to lower ...

Andrew covers the biopharma industry, scientific research, and public health across the continent. You can reach Andrew confidentially on Signal at drewqjoseph.71. Many people who face a heightened ...

Novartis, Amgen and Eli Lilly are among the pharmaceutical companies developing drugs to lower levels of a particularly bad form of cholesterol called Lp(a) and potentially prevent heart attacks. Lp(a ...

With the power to promote plaque build-up, blood clots and inflammation, Lp(a) has been likened to a “triple-headed monster.” (iStock / Getty Images Plus) In the early 1960s, Norwegian physician Kåre ...

LabVIEW通过Linear Programming Simplex Method VI实现多变量线性规划求解，支持最大化 / 最小化目标函数，自动将约束不等式与变量限制转换为标准矩阵形式，输出最优解与目标函数极值。程序通过 ...

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Peter Gabriel fans endured an interminable two-decade wait between the release of his last two albums of original material, 2002’s Up and 2023’s i/o. But they have reason to rejoice today because ...

单纯形法是求解线性规划问题（Linear Programming, LP）的经典算法，用于在一组线性不等式约束下，最大化或最小化一个线性目标函数。 注：若原问题为“最小化”，可转化为最大化 −cᵀx；若 ...