A single family has been described in which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset obesity has not been ...

Epigenetic alterations have been suggested to be associated with obesity and related metabolic disorders. Here we examined the correlation between obesity and insulin resistance with the methylation ...

Anil Oza is a general assignment reporter at STAT focused on the NIH and health equity. You can reach him on Signal at aniloza.16. The hormone leptin was discovered 30 years ago to much fanfare.

Evidence on the association between fatty acids and adiponectin and leptin concentrations is scarce and inconsistent, which may in part be due to limitations of dietary reporting methods. We aimed to ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss. Worldwide obesity rates have ...

Leptin is a hormone that helps manage energy. It signals to your brain when you need food or when you’re satiated. But, leptin resistance can cause the brain to miss this signal, which may contribute ...

Leptin is a key hormone in the regulation of hunger and satiety. For the first time, a large international study has established comprehensive reference values for leptin across all age groups and ...

Leptin is a hormone. Those are chemical messengers that help different body parts work together. Leptin sends a signal to your brain that helps you feel full and less interested in food. You may hear ...

Leptin is a hormone that comes from fat cells. It helps control food intake by sending signals about hunger to the hypothalamus in the brain. This process regulates appetite. Leptin regulates energy ...

Most leptin supplements don’t actually contain the hormone leptin. Research is unclear whether these supplements can help you lose weight, but some studies suggest they can influence leptin ...

Leptin is a hormone – a chemical messenger that helps different body parts work together. Leptin sends a signal to your brain that helps you feel full and less interested in food. You may hear it ...