A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular ...

Inflammatory bowel disease (IBD) and other intestinal disorders affect millions of people worldwide, often causing lasting ...

The intestinal epithelium undergoes one of the most rapid and continuous self‐renewal processes in the human body, driven by a pool of actively cycling Lgr5+ stem cells situated at the base of crypts.

Years before he conducted the research that would earn him a Nobel Prize in Physiology and Medicine, Shinya Yamanaka, MD, PhD, was a postdoctoral scientist at Gladstone Institutes, studying genes.

When inflammation damages the intestinal lining, differentiated enterocytes and crypt base columnar stem cells (CBCs) revert to a regenerative, fetal-like state and form revival stem cells (revSCs).

A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular ...

Researchers have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. A professor of pediatrics-developmental biology and an assistant professor of ...

Periodically abstaining from food helps intestinal stem cells regenerate and heal from injuries—but also increases cancer risk in mice. Intermittent fasting can delay the onset of some age-related ...

Now, scientists have discovered a new role: shaping stem cells, which in turn regulate development. In a study published in Cell Stem Cell, researchers found that metabolites produced by the mother’s ...

A new study reported in Nature has determined that the amino acid cysteine could promote regeneration among cells in the small intestine. The work showed that cysteine can activate an immune signaling ...

A recent study comparing young and aged mouse intestinal tissues revealed a delicate balance between IFN-γ signaling and ERK/MAPK signaling as crucial for maintaining the intestinal stem cell ...