Tangential flow filtration (TFF) is a useful method for separating molecules or particles in liquid solution by size and enables both concentration and the ability to change buffer composition. 1 TFF ...

Dialysis is the passive removal of solutes using a semipermeable membrane whereas dialfiltration is the forced exchange of buffer using pressure. Diafiltration also concentrates samples, but it isn't ...

The importance of liposomes as an effective drug delivery system is well accepted in the pharmaceutical industry, but their handling remains a challenge. The importance of liposomes as an effective ...

Buffer exchange and sample concentration often consume a significant amount of time and require hands-on attention, diverting focus from more important tasks. Big Tuna, an advanced, fully automated ...

Sartoflow Smart from Sartorius Stedim Biotech (SSB) is a benchtop crossflow system for low-volume ultra- and diafiltration applications. Sartoflow Smart from Sartorius Stedim Biotech (SSB) is a ...

Buffer exchange is a critical step to developing optimal vectors and payloads. Compared to biologics, development of delivery vectors like lipid nanoparticles (LNPs) and adeno-associated viruses (AAVs ...

Please could you give our readers an overview of the main functions of Big Tuna? Big Tuna enables automated buffer exchange and sample concentration in most ...